Vergelijking

Exenatide vs. Semaglutid

Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.

Identiteit

Categorie

Metabool

CAS-nr.

141758-74-9

910463-68-2

Molecuulmassa

4186.6 g/mol

4113.6 g/mol

Halfwaardetijd

2.4 h

165 h

Sequentie

HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS

modifiziertes GLP-1-Analogon (31 AS) mit C18-Fettsäure-Linker

Werkingsmechanisme

Exenatide

Exenatide is a 39-amino-acid peptide with about 53% sequence homology to human GLP-1. A glycine substitution at position 2 prevents dipeptidyl-peptidase-IV cleavage and extends the half-life from native GLP-1 (minutes) to about 2.4 hours. GLP-1 receptor activation glucose-dependently stimulates insulin secretion, inhibits glucagon and delays gastric emptying.

Semaglutid

Long-acting agonist at the GLP-1 receptor. Structurally a modified glucagon-like peptide 1 whose long half-life is achieved via a fatty-acid side chain and reversible albumin binding. Acts centrally on satiety and peripherally on glucose-dependent insulin secretion and delayed gastric emptying.

Bewijsbasis

Hoogste bewijs

Humane RCT

Studies

waarvan bij mensen

Geregistreerde effecten

Openstaande tegenstrijdigheden

Gedocumenteerde bijwerkingen

Juridische status

Country	Exenatide	Semaglutid
Zwitserland	—	Op recept
Duitsland	Op recept	Op recept
Verenigde Staten	Op recept	Op recept

Volledige vermeldingen

Exenatide

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Semaglutid

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Frequently asked questions

What is the difference between Exenatide and Semaglutid?: Exenatide is classified as "Metabool", while Semaglutid is classified as "Metabool". Exenatide: Synthetic version of exendin-4, originally isolated from the saliva of the Gila monster (Heloderma suspectum). First GLP-1 receptor agonist, FDA-approved 2005 as Byetta. Weekly depot form Bydureon approved 2012. Semaglutid: Long-acting GLP-1 receptor agonist. Approved as a medicinal product for type-2 diabetes (Ozempic, Rybelsus), chronic weight management (Wegovy) and cardiovascular risk in obesity. One of the best-studied substances on this platform — many large human RCTs. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
Which peptide is better supported by science, Exenatide or Semaglutid?: The highest available evidence level is "Humane RCT" for Exenatide and "Humane RCT" for Semaglutid. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
What is the legal status of Exenatide and Semaglutid in Germany and the United States?: Duitsland: Exenatide — Op recept, Semaglutid — Op recept. Verenigde Staten: Exenatide — Op recept, Semaglutid — Op recept. These are factual summaries with source and review date on the individual pages.

Country

Exenatide

Semaglutid

Zwitserland

—

Op recept

Duitsland

Op recept

Verenigde Staten

Op recept

Frequently asked questions

What is the difference between Exenatide and Semaglutid?

Exenatide is classified as "Metabool", while Semaglutid is classified as "Metabool". Exenatide: Synthetic version of exendin-4, originally isolated from the saliva of the Gila monster (Heloderma suspectum). First GLP-1 receptor agonist, FDA-approved 2005 as Byetta. Weekly depot form Bydureon approved 2012. Semaglutid: Long-acting GLP-1 receptor agonist. Approved as a medicinal product for type-2 diabetes (Ozempic, Rybelsus), chronic weight management (Wegovy) and cardiovascular risk in obesity. One of the best-studied substances on this platform — many large human RCTs. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.

Which peptide is better supported by science, Exenatide or Semaglutid?

The highest available evidence level is "Humane RCT" for Exenatide and "Humane RCT" for Semaglutid. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.

What is the legal status of Exenatide and Semaglutid in Germany and the United States?

Duitsland: Exenatide — Op recept, Semaglutid — Op recept. Verenigde Staten: Exenatide — Op recept, Semaglutid — Op recept. These are factual summaries with source and review date on the individual pages.