Vergelijking
Oxytocin vs. Terlipressin
Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.
Identiteit
Categorie
Onderzoek (overig)
Onderzoek (overig)
CAS-nr.
50-56-6
14636-12-5
Molecuulmassa
1007.19 g/mol
1227.37 g/mol
Halfwaardetijd
0.05 h
geen gegevens
Sequentie
Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2geen gegevens
Werkingsmechanisme
Oxytocin
Oxytocin is synthesised in the hypothalamus and released via the posterior pituitary. Peripherally it binds the oxytocin receptor, a G-protein-coupled receptor, and through the phospholipase-C cascade and calcium release triggers contraction of uterine smooth muscle and milk ejection — the pharmacological basis of the obstetric approval. Centrally, oxytocin acts as a neuromodulator and has been linked to social bonding, trust and modulation of stress and anxiety circuits. Its central effects in humans are mechanistically incompletely understood, particularly because it is unclear to what extent peripherally or intranasally administered oxytocin crosses the blood-brain barrier.
Terlipressin
Terlipressin is slowly converted in the body to lysine-vasopressin by cleavage of the three N-terminal glycyl residues (reservoir effect) and activates V1 receptors. The splanchnic vasoconstriction improves renal perfusion in hepatorenal syndrome.
Bewijsbasis
Hoogste bewijs
Humane RCT
Humane RCT
Studies
4
1
waarvan bij mensen
4
1
Geregistreerde effecten
3
2
Openstaande tegenstrijdigheden
1
0
Gedocumenteerde bijwerkingen
0
1
Juridische status
Volledige vermeldingen
Frequently asked questions
- What is the difference between Oxytocin and Terlipressin?
- Oxytocin is classified as "Onderzoek (overig)", while Terlipressin is classified as "Onderzoek (overig)". Oxytocin: Oxytocin is an endogenous nonapeptide hormone of the posterior pituitary. In synthetic form (Pitocin, Syntocinon) it has been approved for decades to induce and augment labour and to control postpartum uterine bleeding. Strictly separate from this is intranasal use to influence social behaviour, trust, anxiety or autism symptoms: this use is unapproved, purely experimental, and yields inconsistent and often negative results in controlled trials. Terlipressin: Terlipressin is a 12-amino-acid vasopressin analog and prodrug of lysine-vasopressin. As a V1 receptor agonist it is vasoconstrictive and is approved for hepatorenal syndrome (FDA 2022, Terlivaz). This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Oxytocin or Terlipressin?
- The highest available evidence level is "Humane RCT" for Oxytocin and "Humane RCT" for Terlipressin. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Oxytocin and Terlipressin in Germany and the United States?
- Duitsland: Oxytocin — Op recept, Terlipressin — Op recept. Verenigde Staten: Oxytocin — Op recept, Terlipressin — Op recept. These are factual summaries with source and review date on the individual pages.