Vergelijking

Semax vs. Terlipressin

Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.

Identiteit

Categorie

Onderzoek (overig)

CAS-nr.

80714-61-0

14636-12-5

Molecuulmassa

813.92 g/mol

1227.37 g/mol

Halfwaardetijd

0.3 h

geen gegevens

Sequentie

Met-Glu-His-Phe-Pro-Gly-Pro

geen gegevens

Werkingsmechanisme

Semax

Semax is a tetracosactide fragment analog without hormonal activity at MC2R. Proposed mechanisms include elevation of BDNF and NGF in hippocampus and striatum (in animal models), modulation of dopamine metabolism, and neuroprotective effects via anti-apoptotic pathways. A clear primary receptor is not established.

Terlipressin

Terlipressin is slowly converted in the body to lysine-vasopressin by cleavage of the three N-terminal glycyl residues (reservoir effect) and activates V1 receptors. The splanchnic vasoconstriction improves renal perfusion in hepatorenal syndrome.

Bewijsbasis

Hoogste bewijs

Humane studie

Humane RCT

Studies

waarvan bij mensen

Geregistreerde effecten

Openstaande tegenstrijdigheden

Gedocumenteerde bijwerkingen

Juridische status

Country	Semax	Terlipressin
Duitsland	Niet goedgekeurd	Op recept
RU	Op recept	—
Verenigde Staten	Niet goedgekeurd	Op recept

Volledige vermeldingen

Semax

Volledige vermelding →

Terlipressin

Volledige vermelding →

Frequently asked questions

What is the difference between Semax and Terlipressin?: Semax is classified as "Onderzoek (overig)", while Terlipressin is classified as "Onderzoek (overig)". Semax: Synthetic heptapeptide derived from the N-terminal fragment of adrenocorticotropic hormone (ACTH 4-10). Approved in Russia for ischaemic stroke, cognitive function and ADHD in children. Western phase-3 trials absent. Terlipressin: Terlipressin is a 12-amino-acid vasopressin analog and prodrug of lysine-vasopressin. As a V1 receptor agonist it is vasoconstrictive and is approved for hepatorenal syndrome (FDA 2022, Terlivaz). This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
Which peptide is better supported by science, Semax or Terlipressin?: The highest available evidence level is "Humane studie" for Semax and "Humane RCT" for Terlipressin. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
What is the legal status of Semax and Terlipressin in Germany and the United States?: Duitsland: Semax — Niet goedgekeurd, Terlipressin — Op recept. Verenigde Staten: Semax — Niet goedgekeurd, Terlipressin — Op recept. These are factual summaries with source and review date on the individual pages.

Country

Semax

Terlipressin

Duitsland

Niet goedgekeurd

Op recept

—

Verenigde Staten

Niet goedgekeurd

Op recept

Frequently asked questions

What is the difference between Semax and Terlipressin?

Semax is classified as "Onderzoek (overig)", while Terlipressin is classified as "Onderzoek (overig)". Semax: Synthetic heptapeptide derived from the N-terminal fragment of adrenocorticotropic hormone (ACTH 4-10). Approved in Russia for ischaemic stroke, cognitive function and ADHD in children. Western phase-3 trials absent. Terlipressin: Terlipressin is a 12-amino-acid vasopressin analog and prodrug of lysine-vasopressin. As a V1 receptor agonist it is vasoconstrictive and is approved for hepatorenal syndrome (FDA 2022, Terlivaz). This page contrasts both neutrally and source-based — with no usage or dosing recommendation.

Which peptide is better supported by science, Semax or Terlipressin?

The highest available evidence level is "Humane studie" for Semax and "Humane RCT" for Terlipressin. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.

What is the legal status of Semax and Terlipressin in Germany and the United States?

Duitsland: Semax — Niet goedgekeurd, Terlipressin — Op recept. Verenigde Staten: Semax — Niet goedgekeurd, Terlipressin — Op recept. These are factual summaries with source and review date on the individual pages.