AOD-9604 vs. Thymalin

Category

Growth

Healing

CAS no.

221231-10-3

63958-90-7

Molecular weight

1815.09 g/mol

1000 g/mol

Half-life

0.4 h

0.5 h

Sequence

AOD-9604

AOD-9604 corresponds to the C-terminal fragment 176-191 of human growth hormone with an additional N-terminal tyrosine. In animal models, lipolytic effects without GH-typical adverse events (insulin resistance, IGF-1 rise) were reported. In humans, these preclinical findings did not translate into clinically relevant weight reduction in the four phase-2 obesity trials. The exact human mechanism of action is unclear; the GH receptor is not classically activated by the fragment.

Thymalin

Thymalin is a complex of multiple polypeptides extracted from bovine or calf thymus. Postulated mechanisms include modulation of T-lymphocyte maturation, influence on interleukin profiles and stimulation of cellular immune response. Being a multi-component preparation, individual mechanisms are difficult to disentangle. Khavinson and colleagues from St Petersburg have described the mechanism over decades in Russian publications.

Highest evidence

Studies

3

4

of which in humans

2

2

Effects recorded

3

3

Open conflicts

1

1

Documented adverse events

1

1