AOD-9604 vs. Thymosin Alpha-1

Category

Growth

Healing

CAS no.

221231-10-3

62304-98-7

Molecular weight

1815.09 g/mol

3108.32 g/mol

Half-life

0.4 h

2 h

Sequence

AOD-9604

AOD-9604 corresponds to the C-terminal fragment 176-191 of human growth hormone with an additional N-terminal tyrosine. In animal models, lipolytic effects without GH-typical adverse events (insulin resistance, IGF-1 rise) were reported. In humans, these preclinical findings did not translate into clinically relevant weight reduction in the four phase-2 obesity trials. The exact human mechanism of action is unclear; the GH receptor is not classically activated by the fragment.

Thymosin Alpha-1

Thymosin Alpha-1 is an N-terminally acetylated peptide originally isolated from the thymus. It modulates T-lymphocyte maturation and function and acts on dendritic cells via Toll-like receptors (TLR9 / TLR2). In preclinical and some clinical studies, increased interferon-gamma responses and altered T-cell subpopulations have been reported.

Highest evidence

Studies

3

2

of which in humans

2

2

Effects recorded

3

3

Open conflicts

1

1

Documented adverse events

1

1