Argireline vs. Thymosin Alpha-1

Category

Cosmetic

Healing

CAS no.

616204-22-9

62304-98-7

Molecular weight

888.99 g/mol

3108.32 g/mol

Half-life

2 h

Sequence

Argireline

Argireline is a synthetic hexapeptide whose sequence corresponds to the N-terminus of the SNAP-25 protein. In vitro it has been shown to competitively inhibit SNARE complex formation (necessary for vesicle fusion in neurotransmitter release). Topical application is intended — given very limited skin permeation — to attenuate cholinergic signalling at the neuromuscular endplate. The effect is orders of magnitude weaker than intramuscular botulinum toxin; the clinical translatability of the in-vitro observations to the skin microenvironment is contested.

Thymosin Alpha-1

Thymosin Alpha-1 is an N-terminally acetylated peptide originally isolated from the thymus. It modulates T-lymphocyte maturation and function and acts on dendritic cells via Toll-like receptors (TLR9 / TLR2). In preclinical and some clinical studies, increased interferon-gamma responses and altered T-cell subpopulations have been reported.

Highest evidence

Studies

3

2

of which in humans

2

2

Effects recorded

3

3

Open conflicts

1

1

Documented adverse events

1

1