Comparison
BPC-157 vs. SNAP-8
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Healing
Cosmetic
CAS no.
137525-51-0
868844-74-0
Molecular weight
1419.5 g/mol
1075.16 g/mol
Half-life
4 h
no data
Sequence
GEPPPGKPADDAGLVAc-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2Mechanism of action
BPC-157
Synthetic peptide derived from a sequence of a protein found in gastric juice. In preclinical models, an influence on angiogenic and tissue-protective signalling pathways has been described. The precise molecular mechanisms of action are not conclusively understood.
SNAP-8
SNAP-8 is an octapeptide variant of Argireline. The sequence corresponds to the N-terminus of the SNAP-25 protein. As with Argireline, the postulated mechanism is competitive inhibition of the SNARE complex needed for acetylcholine vesicle fusion at the neuromuscular endplate. According to the manufacturer the two extra C-terminal amino acids increase SNARE-complex affinity — there are individual industry studies on this but no independent systematic confirmation.
Evidence base
Highest evidence
Animal model
Human trial
Studies
4
3
of which in humans
0
1
Effects recorded
4
3
Open conflicts
2
0
Documented adverse events
2
1