Comparison
CJC-1295 vs. Thymalin
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Growth
Healing
CAS no.
no data
63958-90-7
Molecular weight
3647.3 g/mol
1000 g/mol
Half-life
144 h
0.5 h
Sequence
YADAIFTNSYRKVLGQLSARKLLQDIMSR-DACno data
Mechanism of action
CJC-1295
Synthetic analogue of growth-hormone-releasing hormone (GHRH), modified for extended half-life via a Drug Affinity Complex (DAC) binding to albumin. Acts on the pituitary GHRH receptor and stimulates endogenous growth-hormone release.
Thymalin
Thymalin is a complex of multiple polypeptides extracted from bovine or calf thymus. Postulated mechanisms include modulation of T-lymphocyte maturation, influence on interleukin profiles and stimulation of cellular immune response. Being a multi-component preparation, individual mechanisms are difficult to disentangle. Khavinson and colleagues from St Petersburg have described the mechanism over decades in Russian publications.
Evidence base
Highest evidence
Human trial
Human trial
Studies
3
4
of which in humans
2
2
Effects recorded
3
3
Open conflicts
1
1
Documented adverse events
3
1