Comparison
CJC-1295 vs. Thymosin Alpha-1
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Growth
Healing
CAS no.
no data
62304-98-7
Molecular weight
3647.3 g/mol
3108.32 g/mol
Half-life
144 h
2 h
Sequence
YADAIFTNSYRKVLGQLSARKLLQDIMSR-DACAc-SDAAVDTSSEITTKDLKEKKEVVEEAENMechanism of action
CJC-1295
Synthetic analogue of growth-hormone-releasing hormone (GHRH), modified for extended half-life via a Drug Affinity Complex (DAC) binding to albumin. Acts on the pituitary GHRH receptor and stimulates endogenous growth-hormone release.
Thymosin Alpha-1
Thymosin Alpha-1 is an N-terminally acetylated peptide originally isolated from the thymus. It modulates T-lymphocyte maturation and function and acts on dendritic cells via Toll-like receptors (TLR9 / TLR2). In preclinical and some clinical studies, increased interferon-gamma responses and altered T-cell subpopulations have been reported.
Evidence base
Highest evidence
Human trial
Human RCT
Studies
3
2
of which in humans
2
2
Effects recorded
3
3
Open conflicts
1
1
Documented adverse events
3
1