Comparison
Epitalon vs. Ipamorelin
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Research other
Growth
CAS no.
307297-39-8
170851-70-4
Molecular weight
390.35 g/mol
711.86 g/mol
Half-life
0.3 h
2 h
Sequence
Ala-Glu-Asp-GlyAib-His-D-2-Nal-D-Phe-Lys-NH2Mechanism of action
Epitalon
Postulated mechanisms include modulation of gene expression in pinealocytes, telomerase activation (observed in cell culture studies) and influence on melatonin synthesis. A defined primary receptor is not established; the mechanistic basis rests on in-vitro and animal data from the Khavinson group.
Ipamorelin
Ipamorelin is a selective agonist at the GH secretagogue receptor (GHSR-1a). Compared to GHRP-2 and GHRP-6 its selectivity for the growth-hormone axis is higher; ACTH, cortisol and prolactin are not significantly stimulated in clinical studies. This selectivity was the main reason for its development over older GHRPs.
Evidence base
Highest evidence
Human trial
Human RCT
Studies
4
4
of which in humans
1
3
Effects recorded
4
3
Open conflicts
1
1
Documented adverse events
1
1