Comparison
Epitalon vs. Matrixyl
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Research other
Cosmetic
CAS no.
307297-39-8
214047-00-4
Molecular weight
390.35 g/mol
802.06 g/mol
Half-life
0.3 h
no data
Sequence
Ala-Glu-Asp-GlyPalmitoyl-Lys-Thr-Thr-Lys-SerMechanism of action
Epitalon
Postulated mechanisms include modulation of gene expression in pinealocytes, telomerase activation (observed in cell culture studies) and influence on melatonin synthesis. A defined primary receptor is not established; the mechanistic basis rests on in-vitro and animal data from the Khavinson group.
Matrixyl
KTTKS is a fragment of the procollagen I sequence and appears to be part of a feedback mechanism in fibroblasts: elevated concentrations signal intact collagen synthesis and downregulate new synthesis, while low concentrations stimulate it. In cell-culture studies, stimulation of collagen types I/III, elastin, fibronectin and glycosaminoglycans has been documented. The palmitoyl modification is intended to improve skin penetration; effect at the site of action (dermal fibroblasts) depends on permeation.
Evidence base
Highest evidence
Human trial
Human RCT
Studies
4
5
of which in humans
1
2
Effects recorded
4
3
Open conflicts
1
0
Documented adverse events
1
1