Comparison
Epitalon vs. Sermorelin
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Research other
Growth
CAS no.
307297-39-8
86168-78-7
Molecular weight
390.35 g/mol
3358 g/mol
Half-life
0.3 h
0.2 h
Sequence
Ala-Glu-Asp-GlyYADAIFTNSYRKVLGQLSARKLLQDIMSRMechanism of action
Epitalon
Postulated mechanisms include modulation of gene expression in pinealocytes, telomerase activation (observed in cell culture studies) and influence on melatonin synthesis. A defined primary receptor is not established; the mechanistic basis rests on in-vitro and animal data from the Khavinson group.
Sermorelin
Synthetic analogue of the first 29 amino acids of human growth-hormone-releasing hormone (GHRH). Stimulates pulsatile endogenous growth-hormone secretion from the pituitary via the GHRH receptor. Very short plasma half-life — pharmacodynamic effect lasts several hours nevertheless.
Evidence base
Highest evidence
Human trial
Human RCT
Studies
4
5
of which in humans
1
3
Effects recorded
4
3
Open conflicts
1
1
Documented adverse events
1
3