Comparison
Epitalon vs. Survodutide
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Research other
Metabolic
CAS no.
307297-39-8
2179963-22-7
Molecular weight
390.35 g/mol
4727 g/mol
Half-life
0.3 h
168 h
Sequence
Ala-Glu-Asp-Glymodifiziertes 29-Aminosäuren-Peptid mit FettsäureseitenketteMechanism of action
Epitalon
Postulated mechanisms include modulation of gene expression in pinealocytes, telomerase activation (observed in cell culture studies) and influence on melatonin synthesis. A defined primary receptor is not established; the mechanistic basis rests on in-vitro and animal data from the Khavinson group.
Survodutide
Survodutide is a dual agonist at the GLP-1 and glucagon receptors. The GLP-1 component mediates glucose-dependent insulin secretion, inhibition of glucagon secretion at high blood glucose and modulation of satiety. The glucagon component raises basal energy expenditure via hepatic and brown adipocyte effects. A fatty-acid side chain enables albumin binding and weekly dosing.
Evidence base
Highest evidence
Human trial
Human RCT
Studies
4
2
of which in humans
1
2
Effects recorded
4
3
Open conflicts
1
0
Documented adverse events
1
2