Comparison
Epitalon vs. TB-500
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Research other
Healing
CAS no.
307297-39-8
no data
Molecular weight
390.35 g/mol
888 g/mol
Half-life
0.3 h
no data
Sequence
Ala-Glu-Asp-GlyAc-LKKTETQMechanism of action
Epitalon
Postulated mechanisms include modulation of gene expression in pinealocytes, telomerase activation (observed in cell culture studies) and influence on melatonin synthesis. A defined primary receptor is not established; the mechanistic basis rests on in-vitro and animal data from the Khavinson group.
TB-500
Synthetic fragment of the endogenous protein Thymosin Beta-4. In preclinical models, an influence on cell migration, actin sequestration and neovascularisation has been described. Robust human pharmacokinetic data are not publicly available.
Evidence base
Highest evidence
Human trial
Animal model
Studies
4
3
of which in humans
1
0
Effects recorded
4
4
Open conflicts
1
1
Documented adverse events
1
2