Epitalon vs. Thymosin Alpha-1

Category

Research other

Healing

CAS no.

307297-39-8

62304-98-7

Molecular weight

390.35 g/mol

3108.32 g/mol

Half-life

0.3 h

2 h

Sequence

Epitalon

Postulated mechanisms include modulation of gene expression in pinealocytes, telomerase activation (observed in cell culture studies) and influence on melatonin synthesis. A defined primary receptor is not established; the mechanistic basis rests on in-vitro and animal data from the Khavinson group.

Thymosin Alpha-1

Thymosin Alpha-1 is an N-terminally acetylated peptide originally isolated from the thymus. It modulates T-lymphocyte maturation and function and acts on dendritic cells via Toll-like receptors (TLR9 / TLR2). In preclinical and some clinical studies, increased interferon-gamma responses and altered T-cell subpopulations have been reported.

Highest evidence

Studies

4

2

of which in humans

1

2

Effects recorded

4

3

Open conflicts

1

1

Documented adverse events

1

1