Comparison
GHK-Cu vs. Ipamorelin
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Cosmetic
Growth
CAS no.
49557-75-7
170851-70-4
Molecular weight
340.4 g/mol
711.86 g/mol
Half-life
no data
2 h
Sequence
GHKAib-His-D-2-Nal-D-Phe-Lys-NH2Mechanism of action
GHK-Cu
Endogenous tripeptide (glycyl-L-histidyl-L-lysine) that chelates copper(II) ions. In skin-cell models and skin biopsies an influence on collagen synthesis, antioxidant markers, gene-expression profiles and wound-healing processes has been described. In topical use in cosmetic studies, changes in various skin parameters have been reported.
Ipamorelin
Ipamorelin is a selective agonist at the GH secretagogue receptor (GHSR-1a). Compared to GHRP-2 and GHRP-6 its selectivity for the growth-hormone axis is higher; ACTH, cortisol and prolactin are not significantly stimulated in clinical studies. This selectivity was the main reason for its development over older GHRPs.
Evidence base
Highest evidence
Human trial
Human RCT
Studies
3
4
of which in humans
1
3
Effects recorded
4
3
Open conflicts
1
1
Documented adverse events
2
1