Comparison
GHK-Cu vs. Thymosin Alpha-1
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Cosmetic
Healing
CAS no.
49557-75-7
62304-98-7
Molecular weight
340.4 g/mol
3108.32 g/mol
Half-life
no data
2 h
Sequence
GHKAc-SDAAVDTSSEITTKDLKEKKEVVEEAENMechanism of action
GHK-Cu
Endogenous tripeptide (glycyl-L-histidyl-L-lysine) that chelates copper(II) ions. In skin-cell models and skin biopsies an influence on collagen synthesis, antioxidant markers, gene-expression profiles and wound-healing processes has been described. In topical use in cosmetic studies, changes in various skin parameters have been reported.
Thymosin Alpha-1
Thymosin Alpha-1 is an N-terminally acetylated peptide originally isolated from the thymus. It modulates T-lymphocyte maturation and function and acts on dendritic cells via Toll-like receptors (TLR9 / TLR2). In preclinical and some clinical studies, increased interferon-gamma responses and altered T-cell subpopulations have been reported.
Evidence base
Highest evidence
Human trial
Human RCT
Studies
3
2
of which in humans
1
2
Effects recorded
4
3
Open conflicts
1
1
Documented adverse events
2
1