Comparison
Ipamorelin vs. TB-500
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Growth
Healing
CAS no.
170851-70-4
no data
Molecular weight
711.86 g/mol
888 g/mol
Half-life
2 h
no data
Sequence
Aib-His-D-2-Nal-D-Phe-Lys-NH2Ac-LKKTETQMechanism of action
Ipamorelin
Ipamorelin is a selective agonist at the GH secretagogue receptor (GHSR-1a). Compared to GHRP-2 and GHRP-6 its selectivity for the growth-hormone axis is higher; ACTH, cortisol and prolactin are not significantly stimulated in clinical studies. This selectivity was the main reason for its development over older GHRPs.
TB-500
Synthetic fragment of the endogenous protein Thymosin Beta-4. In preclinical models, an influence on cell migration, actin sequestration and neovascularisation has been described. Robust human pharmacokinetic data are not publicly available.
Evidence base
Highest evidence
Human RCT
Animal model
Studies
4
3
of which in humans
3
0
Effects recorded
3
4
Open conflicts
1
1
Documented adverse events
1
2