Comparison
Matrixyl vs. Sermorelin
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Cosmetic
Growth
CAS no.
214047-00-4
86168-78-7
Molecular weight
802.06 g/mol
3358 g/mol
Half-life
no data
0.2 h
Sequence
Palmitoyl-Lys-Thr-Thr-Lys-SerYADAIFTNSYRKVLGQLSARKLLQDIMSRMechanism of action
Matrixyl
KTTKS is a fragment of the procollagen I sequence and appears to be part of a feedback mechanism in fibroblasts: elevated concentrations signal intact collagen synthesis and downregulate new synthesis, while low concentrations stimulate it. In cell-culture studies, stimulation of collagen types I/III, elastin, fibronectin and glycosaminoglycans has been documented. The palmitoyl modification is intended to improve skin penetration; effect at the site of action (dermal fibroblasts) depends on permeation.
Sermorelin
Synthetic analogue of the first 29 amino acids of human growth-hormone-releasing hormone (GHRH). Stimulates pulsatile endogenous growth-hormone secretion from the pituitary via the GHRH receptor. Very short plasma half-life — pharmacodynamic effect lasts several hours nevertheless.
Evidence base
Highest evidence
Human RCT
Human RCT
Studies
5
5
of which in humans
2
3
Effects recorded
3
3
Open conflicts
0
1
Documented adverse events
1
3