Comparison
MGF (Mechano Growth Factor) vs. Thymalin
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Growth
Healing
CAS no.
12-Aminosäuren-C-terminales E-Domänen-Peptid (Sequenz nicht standardisiert)
63958-90-7
Molecular weight
2867.2 g/mol
1000 g/mol
Half-life
0.1 h
0.5 h
Sequence
YQPPSTNKNTKSQRRKGSTFEERKno data
Mechanism of action
MGF (Mechano Growth Factor)
The IGF-1 gene produces multiple isoforms by alternative splicing. IGF-1Ec is upregulated after mechanical muscle loading; the C-terminal E-domain is cleaved from the mature IGF-1 protein and appears to have independent effects on satellite cells. The exact receptor binding of the E-domain is not established; a classical IGF-1R effect is unlikely since mature IGF-1 is responsible. In cell-culture studies, stimulation of myoblast proliferation and differentiation has been observed.
Thymalin
Thymalin is a complex of multiple polypeptides extracted from bovine or calf thymus. Postulated mechanisms include modulation of T-lymphocyte maturation, influence on interleukin profiles and stimulation of cellular immune response. Being a multi-component preparation, individual mechanisms are difficult to disentangle. Khavinson and colleagues from St Petersburg have described the mechanism over decades in Russian publications.
Evidence base
Highest evidence
Animal model
Human trial
Studies
4
4
of which in humans
0
2
Effects recorded
3
3
Open conflicts
0
1
Documented adverse events
1
1