Comparison
Bremelanotide vs. TB-500
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Research other
Healing
CAS no.
189691-06-3
no data
Molecular weight
1025.18 g/mol
888 g/mol
Half-life
2.7 h
no data
Sequence
Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-OHAc-LKKTETQMechanism of action
Bremelanotide
Bremelanotide is a cyclic peptide that binds non-selectively to melanocortin receptors (MC1R through MC5R) — with highest affinity at MC4R in the central nervous system. The precise role of MC4R activation in sexual behaviour is not fully understood; animal data show effects on hypothalamic circuits. Peripheral effects (blood pressure, hyperpigmentation) are attributed to MC1R/MC2R.
TB-500
Synthetic fragment of the endogenous protein Thymosin Beta-4. In preclinical models, an influence on cell migration, actin sequestration and neovascularisation has been described. Robust human pharmacokinetic data are not publicly available.
Evidence base
Highest evidence
Human RCT
Animal model
Studies
5
3
of which in humans
5
0
Effects recorded
3
4
Open conflicts
0
1
Documented adverse events
2
2