Comparison
Retatrutide vs. Thymalin
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Metabolic
Healing
CAS no.
2381089-83-2
63958-90-7
Molecular weight
4731.6 g/mol
1000 g/mol
Half-life
144 h
0.5 h
Sequence
Y-Aib-EGTFTSDYSIYLDKQAAQDFVQWLLDTGPSSGAPPPSno data
Mechanism of action
Retatrutide
Retatrutide is a 39-amino-acid peptide with agonism at three incretin/energy-balance receptors: GLP-1R (insulin secretion, satiety), GIPR (insulin sensitivity, lipid metabolism) and the glucagon receptor (energy expenditure, lipolysis). The added glucagon activation is intended to raise catabolic energy expenditure while concurrent GLP-1/GIP action compensates the hyperglycaemic effect. Albumin binding via a fatty-acid side chain enables weekly dosing.
Thymalin
Thymalin is a complex of multiple polypeptides extracted from bovine or calf thymus. Postulated mechanisms include modulation of T-lymphocyte maturation, influence on interleukin profiles and stimulation of cellular immune response. Being a multi-component preparation, individual mechanisms are difficult to disentangle. Khavinson and colleagues from St Petersburg have described the mechanism over decades in Russian publications.
Evidence base
Highest evidence
Human RCT
Human trial
Studies
5
4
of which in humans
4
2
Effects recorded
4
3
Open conflicts
0
1
Documented adverse events
2
1