Comparison
Sermorelin vs. TB-500
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Growth
Healing
CAS no.
86168-78-7
no data
Molecular weight
3358 g/mol
888 g/mol
Half-life
0.2 h
no data
Sequence
YADAIFTNSYRKVLGQLSARKLLQDIMSRAc-LKKTETQMechanism of action
Sermorelin
Synthetic analogue of the first 29 amino acids of human growth-hormone-releasing hormone (GHRH). Stimulates pulsatile endogenous growth-hormone secretion from the pituitary via the GHRH receptor. Very short plasma half-life — pharmacodynamic effect lasts several hours nevertheless.
TB-500
Synthetic fragment of the endogenous protein Thymosin Beta-4. In preclinical models, an influence on cell migration, actin sequestration and neovascularisation has been described. Robust human pharmacokinetic data are not publicly available.
Evidence base
Highest evidence
Human RCT
Animal model
Studies
5
3
of which in humans
3
0
Effects recorded
3
4
Open conflicts
1
1
Documented adverse events
3
2