Comparison
Sermorelin vs. Thymosin Alpha-1
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Growth
Healing
CAS no.
86168-78-7
62304-98-7
Molecular weight
3358 g/mol
3108.32 g/mol
Half-life
0.2 h
2 h
Sequence
YADAIFTNSYRKVLGQLSARKLLQDIMSRAc-SDAAVDTSSEITTKDLKEKKEVVEEAENMechanism of action
Sermorelin
Synthetic analogue of the first 29 amino acids of human growth-hormone-releasing hormone (GHRH). Stimulates pulsatile endogenous growth-hormone secretion from the pituitary via the GHRH receptor. Very short plasma half-life — pharmacodynamic effect lasts several hours nevertheless.
Thymosin Alpha-1
Thymosin Alpha-1 is an N-terminally acetylated peptide originally isolated from the thymus. It modulates T-lymphocyte maturation and function and acts on dendritic cells via Toll-like receptors (TLR9 / TLR2). In preclinical and some clinical studies, increased interferon-gamma responses and altered T-cell subpopulations have been reported.
Evidence base
Highest evidence
Human RCT
Human RCT
Studies
5
2
of which in humans
3
2
Effects recorded
3
3
Open conflicts
1
1
Documented adverse events
3
1