Comparison
SNAP-8 vs. Thymosin Alpha-1
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Cosmetic
Healing
CAS no.
868844-74-0
62304-98-7
Molecular weight
1075.16 g/mol
3108.32 g/mol
Half-life
no data
2 h
Sequence
Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2Ac-SDAAVDTSSEITTKDLKEKKEVVEEAENMechanism of action
SNAP-8
SNAP-8 is an octapeptide variant of Argireline. The sequence corresponds to the N-terminus of the SNAP-25 protein. As with Argireline, the postulated mechanism is competitive inhibition of the SNARE complex needed for acetylcholine vesicle fusion at the neuromuscular endplate. According to the manufacturer the two extra C-terminal amino acids increase SNARE-complex affinity — there are individual industry studies on this but no independent systematic confirmation.
Thymosin Alpha-1
Thymosin Alpha-1 is an N-terminally acetylated peptide originally isolated from the thymus. It modulates T-lymphocyte maturation and function and acts on dendritic cells via Toll-like receptors (TLR9 / TLR2). In preclinical and some clinical studies, increased interferon-gamma responses and altered T-cell subpopulations have been reported.
Evidence base
Highest evidence
Human trial
Human RCT
Studies
3
2
of which in humans
1
2
Effects recorded
3
3
Open conflicts
0
1
Documented adverse events
1
1