La desmopresina es un análogo de la vasopresina (ADH) aprobado para la diabetes insípida central, la enuresis y ciertos trastornos hemostáticos.
Desmopressin is a structurally modified analogue of the nine-residue peptide hormone vasopressin. Deamination at the N-terminus (1-deamino) and replacement of L-arginine by D-arginine at position 8 prolong the duration of action and render the compound largely selective for the vasopressin V2 receptor, while the V1-mediated vasoconstrictive effect is strongly reduced. Acting on V2 receptors in the renal collecting ducts, it promotes insertion of aquaporin-2 water channels into the apical membrane, increasing water reabsorption and reducing urine volume (antidiuretic effect). In addition, via V2 receptors on the vascular endothelium, desmopressin stimulates the release of von Willebrand factor and factor VIII from endothelial stores (Weibel-Palade bodies), improving primary haemostasis.
Curva teórica de concentración con una semivida de 3 h. Modelo farmacocinético puro — no es una recomendación de dosis.
Open in PK tool →Desmopressin can lead to water retention and consequent hyponatremia; careful restriction of fluid intake and monitoring of serum sodium are emphasised in the labeling.
Los péptidos vienen como polvo seco. Una vez disuelto en un líquido (reconstitución), esta calculadora responde a una única pregunta: ¿cuánta sustancia hay en un mililitro de solución después?
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