Vergelijking
Cagrilintide vs. Exenatide
Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.
Identiteit
Categorie
Metabool
Metabool
CAS-nr.
1415456-99-3
141758-74-9
Molecuulmassa
4253.7 g/mol
4186.6 g/mol
Halfwaardetijd
168 h
2.4 h
Sequentie
KCNTATCATQRLANFLVRSSNNLGPVLPPTNVGSNTYHGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPSWerkingsmechanisme
Cagrilintide
Cagrilintide binds amylin receptors (AMY1, AMY3, formed by the calcitonin receptor plus RAMP proteins). Activation delays gastric emptying, inhibits postprandial glucagon secretion and modulates central satiety signalling via area postrema neurons. An acyl modification enables albumin binding and thereby weekly dosing.
Exenatide
Exenatide is a 39-amino-acid peptide with about 53% sequence homology to human GLP-1. A glycine substitution at position 2 prevents dipeptidyl-peptidase-IV cleavage and extends the half-life from native GLP-1 (minutes) to about 2.4 hours. GLP-1 receptor activation glucose-dependently stimulates insulin secretion, inhibits glucagon and delays gastric emptying.
Bewijsbasis
Hoogste bewijs
Humane RCT
Humane RCT
Studies
4
5
waarvan bij mensen
3
4
Geregistreerde effecten
3
3
Openstaande tegenstrijdigheden
1
1
Gedocumenteerde bijwerkingen
1
2
Juridische status
Volledige vermeldingen
Frequently asked questions
- What is the difference between Cagrilintide and Exenatide?
- Cagrilintide is classified as "Metabool", while Exenatide is classified as "Metabool". Cagrilintide: Synthetic long-acting amylin analog being developed in combination with semaglutide (CagriSema). Phase 3 trials for obesity and type 2 diabetes are ongoing. No marketing approval yet. Exenatide: Synthetic version of exendin-4, originally isolated from the saliva of the Gila monster (Heloderma suspectum). First GLP-1 receptor agonist, FDA-approved 2005 as Byetta. Weekly depot form Bydureon approved 2012. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Cagrilintide or Exenatide?
- The highest available evidence level is "Humane RCT" for Cagrilintide and "Humane RCT" for Exenatide. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Cagrilintide and Exenatide in Germany and the United States?
- Duitsland: Cagrilintide — Niet goedgekeurd, Exenatide — Op recept. Verenigde Staten: Cagrilintide — Niet goedgekeurd, Exenatide — Op recept. These are factual summaries with source and review date on the individual pages.