Vergelijking

Selank vs. Sincalide

Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.

Identiteit

Categorie

Onderzoek (overig)

CAS-nr.

129954-34-3

25126-32-3

Molecuulmassa

751.85 g/mol

1143.29 g/mol

Halfwaardetijd

0.3 h

geen gegevens

Sequentie

Thr-Lys-Pro-Arg-Pro-Gly-Pro

Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2

Werkingsmechanisme

Selank

Selank is a glyproline-tuftsin analog. Proposed mechanisms include modulation of the GABAergic system, effects on serotonin bioavailability, and influence on enkephalinases. Animal studies show anxiolytic and neuroprotective markers; a clear receptor target is not established.

Sincalide

Sincalide activates CCK receptors, triggering gallbladder contraction and pancreatic enzyme secretion. This effect is used diagnostically to measure the gallbladder ejection fraction (e.g. in HIDA scintigraphy).

Bewijsbasis

Hoogste bewijs

Humane studie

Studies

waarvan bij mensen

Geregistreerde effecten

Openstaande tegenstrijdigheden

Gedocumenteerde bijwerkingen

Juridische status

Country	Selank	Sincalide
Duitsland	Niet goedgekeurd	Onduidelijk
RU	Op recept	—
Verenigde Staten	Niet goedgekeurd	Op recept

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Selank

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Sincalide

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Frequently asked questions

What is the difference between Selank and Sincalide?: Selank is classified as "Onderzoek (overig)", while Sincalide is classified as "Onderzoek (overig)". Selank: Synthetic heptapeptide derived from natural tuftsin. Approved as an anxiolytic (Selank) in Russia and some CIS states. Western phase-3 trials are absent; efficacy assessment relies on Russian research literature. Sincalide: Sincalide is the synthetic C-terminal octapeptide of the hormone cholecystokinin (CCK-8). As Kinevac it is FDA-approved to stimulate gallbladder contraction for diagnostic imaging. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
Which peptide is better supported by science, Selank or Sincalide?: The highest available evidence level is "Humane studie" for Selank and "Humane studie" for Sincalide. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
What is the legal status of Selank and Sincalide in Germany and the United States?: Duitsland: Selank — Niet goedgekeurd, Sincalide — Onduidelijk. Verenigde Staten: Selank — Niet goedgekeurd, Sincalide — Op recept. These are factual summaries with source and review date on the individual pages.

Country

Selank

Sincalide

Duitsland

Niet goedgekeurd

Onduidelijk

Op recept

—

Verenigde Staten

Niet goedgekeurd

Op recept

Frequently asked questions

What is the difference between Selank and Sincalide?

Selank is classified as "Onderzoek (overig)", while Sincalide is classified as "Onderzoek (overig)". Selank: Synthetic heptapeptide derived from natural tuftsin. Approved as an anxiolytic (Selank) in Russia and some CIS states. Western phase-3 trials are absent; efficacy assessment relies on Russian research literature. Sincalide: Sincalide is the synthetic C-terminal octapeptide of the hormone cholecystokinin (CCK-8). As Kinevac it is FDA-approved to stimulate gallbladder contraction for diagnostic imaging. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.

Which peptide is better supported by science, Selank or Sincalide?

The highest available evidence level is "Humane studie" for Selank and "Humane studie" for Sincalide. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.

What is the legal status of Selank and Sincalide in Germany and the United States?

Duitsland: Selank — Niet goedgekeurd, Sincalide — Onduidelijk. Verenigde Staten: Selank — Niet goedgekeurd, Sincalide — Op recept. These are factual summaries with source and review date on the individual pages.