Comparison
Selank vs. Sincalide
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Research other
Research other
CAS no.
129954-34-3
25126-32-3
Molecular weight
751.85 g/mol
1143.29 g/mol
Half-life
0.3 h
no data
Sequence
Thr-Lys-Pro-Arg-Pro-Gly-ProAsp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2Mechanism of action
Selank
Selank is a glyproline-tuftsin analog. Proposed mechanisms include modulation of the GABAergic system, effects on serotonin bioavailability, and influence on enkephalinases. Animal studies show anxiolytic and neuroprotective markers; a clear receptor target is not established.
Sincalide
Sincalide activates CCK receptors, triggering gallbladder contraction and pancreatic enzyme secretion. This effect is used diagnostically to measure the gallbladder ejection fraction (e.g. in HIDA scintigraphy).
Evidence base
Highest evidence
Human trial
Human trial
Studies
4
0
of which in humans
2
0
Effects recorded
3
1
Open conflicts
1
0
Documented adverse events
1
1
Legal status
Full entries
Frequently asked questions
- What is the difference between Selank and Sincalide?
- Selank is classified as "Research other", while Sincalide is classified as "Research other". Selank: Synthetic heptapeptide derived from natural tuftsin. Approved as an anxiolytic (Selank) in Russia and some CIS states. Western phase-3 trials are absent; efficacy assessment relies on Russian research literature. Sincalide: Sincalide is the synthetic C-terminal octapeptide of the hormone cholecystokinin (CCK-8). As Kinevac it is FDA-approved to stimulate gallbladder contraction for diagnostic imaging. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Selank or Sincalide?
- The highest available evidence level is "Human trial" for Selank and "Human trial" for Sincalide. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Selank and Sincalide in Germany and the United States?
- Germany: Selank — Unapproved, Sincalide — Unclear. United States: Selank — Unapproved, Sincalide — Prescription. These are factual summaries with source and review date on the individual pages.