Vergelijking
Tirzepatide vs. VK2735
Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.
Identiteit
Categorie
Metabool
Metabool
CAS-nr.
2023788-19-2
geen gegevens
Molecuulmassa
4813 g/mol
geen gegevens
Halfwaardetijd
116 h
geen gegevens
Sequentie
YXEGTFTSDYSIYLDKIAQKAFVQWLIAGGPSSGAPPPSgeen gegevens
Werkingsmechanisme
Tirzepatide
Tirzepatide is a 39-amino-acid peptide acting as a dual agonist at the GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide) receptors. Activation of both incretin receptors via G-protein-coupled signalling raises insulin secretion in a glucose-dependent manner, lowers glucagon secretion and delays gastric emptying. Centrally, satiety perception is modulated. A fatty-acid side chain binds to serum albumin and extends the half-life to about five days.
VK2735
VK2735 activates both the GLP-1 and the GIP receptor — a dual mechanism similar to that of tirzepatide, suppressing appetite and food intake.
Bewijsbasis
Hoogste bewijs
Humane RCT
Humane RCT
Studies
4
1
waarvan bij mensen
4
1
Geregistreerde effecten
4
2
Openstaande tegenstrijdigheden
1
0
Gedocumenteerde bijwerkingen
2
1
Juridische status
Volledige vermeldingen
Frequently asked questions
- What is the difference between Tirzepatide and VK2735?
- Tirzepatide is classified as "Metabool", while VK2735 is classified as "Metabool". Tirzepatide: Synthetic peptide that simultaneously activates the GLP-1 and GIP receptor (dual agonist). Approved in the US and EU for type 2 diabetes (Mounjaro) and obesity (Zepbound). VK2735: VK2735 is a dual GLP-1/GIP receptor agonist from Viking Therapeutics, in development in both subcutaneous and oral forms for obesity. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Tirzepatide or VK2735?
- The highest available evidence level is "Humane RCT" for Tirzepatide and "Humane RCT" for VK2735. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Tirzepatide and VK2735 in Germany and the United States?
- Duitsland: Tirzepatide — Op recept, VK2735 — Niet goedgekeurd. Verenigde Staten: Tirzepatide — Op recept, VK2735 — Niet goedgekeurd. These are factual summaries with source and review date on the individual pages.