AOD-9604 vs. MGF (Mechano Growth Factor)

Category

Growth

Growth

CAS no.

221231-10-3

12-Aminosäuren-C-terminales E-Domänen-Peptid (Sequenz nicht standardisiert)

Molecular weight

1815.09 g/mol

2867.2 g/mol

Half-life

0.4 h

0.1 h

Sequence

AOD-9604

AOD-9604 corresponds to the C-terminal fragment 176-191 of human growth hormone with an additional N-terminal tyrosine. In animal models, lipolytic effects without GH-typical adverse events (insulin resistance, IGF-1 rise) were reported. In humans, these preclinical findings did not translate into clinically relevant weight reduction in the four phase-2 obesity trials. The exact human mechanism of action is unclear; the GH receptor is not classically activated by the fragment.

MGF (Mechano Growth Factor)

The IGF-1 gene produces multiple isoforms by alternative splicing. IGF-1Ec is upregulated after mechanical muscle loading; the C-terminal E-domain is cleaved from the mature IGF-1 protein and appears to have independent effects on satellite cells. The exact receptor binding of the E-domain is not established; a classical IGF-1R effect is unlikely since mature IGF-1 is responsible. In cell-culture studies, stimulation of myoblast proliferation and differentiation has been observed.

Highest evidence

Studies

3

4

of which in humans

2

0

Effects recorded

3

3

Open conflicts

1

0

Documented adverse events

1

1