Comparison
Argireline vs. Selank
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Cosmetic
Research other
CAS no.
616204-22-9
129954-34-3
Molecular weight
888.99 g/mol
751.85 g/mol
Half-life
no data
0.3 h
Sequence
Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2Thr-Lys-Pro-Arg-Pro-Gly-ProMechanism of action
Argireline
Argireline is a synthetic hexapeptide whose sequence corresponds to the N-terminus of the SNAP-25 protein. In vitro it has been shown to competitively inhibit SNARE complex formation (necessary for vesicle fusion in neurotransmitter release). Topical application is intended — given very limited skin permeation — to attenuate cholinergic signalling at the neuromuscular endplate. The effect is orders of magnitude weaker than intramuscular botulinum toxin; the clinical translatability of the in-vitro observations to the skin microenvironment is contested.
Selank
Selank is a glyproline-tuftsin analog. Proposed mechanisms include modulation of the GABAergic system, effects on serotonin bioavailability, and influence on enkephalinases. Animal studies show anxiolytic and neuroprotective markers; a clear receptor target is not established.
Evidence base
Highest evidence
Human trial
Human trial
Studies
3
4
of which in humans
2
2
Effects recorded
3
3
Open conflicts
1
0
Documented adverse events
1
1