Comparison
BPC-157 vs. GHK-Cu
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Healing
Cosmetic
CAS no.
137525-51-0
49557-75-7
Molecular weight
1419.5 g/mol
340.4 g/mol
Half-life
4 h
no data
Sequence
GEPPPGKPADDAGLVGHKMechanism of action
BPC-157
Synthetic peptide derived from a sequence of a protein found in gastric juice. In preclinical models, an influence on angiogenic and tissue-protective signalling pathways has been described. The precise molecular mechanisms of action are not conclusively understood.
GHK-Cu
Endogenous tripeptide (glycyl-L-histidyl-L-lysine) that chelates copper(II) ions. In skin-cell models and skin biopsies an influence on collagen synthesis, antioxidant markers, gene-expression profiles and wound-healing processes has been described. In topical use in cosmetic studies, changes in various skin parameters have been reported.
Evidence base
Highest evidence
Animal model
Human trial
Studies
4
3
of which in humans
0
1
Effects recorded
4
4
Open conflicts
2
1
Documented adverse events
2
2