Comparison
BPC-157 vs. Matrixyl
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Healing
Cosmetic
CAS no.
137525-51-0
214047-00-4
Molecular weight
1419.5 g/mol
802.06 g/mol
Half-life
4 h
no data
Sequence
GEPPPGKPADDAGLVPalmitoyl-Lys-Thr-Thr-Lys-SerMechanism of action
BPC-157
Synthetic peptide derived from a sequence of a protein found in gastric juice. In preclinical models, an influence on angiogenic and tissue-protective signalling pathways has been described. The precise molecular mechanisms of action are not conclusively understood.
Matrixyl
KTTKS is a fragment of the procollagen I sequence and appears to be part of a feedback mechanism in fibroblasts: elevated concentrations signal intact collagen synthesis and downregulate new synthesis, while low concentrations stimulate it. In cell-culture studies, stimulation of collagen types I/III, elastin, fibronectin and glycosaminoglycans has been documented. The palmitoyl modification is intended to improve skin penetration; effect at the site of action (dermal fibroblasts) depends on permeation.
Evidence base
Highest evidence
Animal model
Human RCT
Studies
4
5
of which in humans
0
2
Effects recorded
4
3
Open conflicts
2
0
Documented adverse events
2
1