Comparison
BPC-157 vs. Semax
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Healing
Research other
CAS no.
137525-51-0
80714-61-0
Molecular weight
1419.5 g/mol
813.92 g/mol
Half-life
4 h
0.3 h
Sequence
GEPPPGKPADDAGLVMet-Glu-His-Phe-Pro-Gly-ProMechanism of action
BPC-157
Synthetic peptide derived from a sequence of a protein found in gastric juice. In preclinical models, an influence on angiogenic and tissue-protective signalling pathways has been described. The precise molecular mechanisms of action are not conclusively understood.
Semax
Semax is a tetracosactide fragment analog without hormonal activity at MC2R. Proposed mechanisms include elevation of BDNF and NGF in hippocampus and striatum (in animal models), modulation of dopamine metabolism, and neuroprotective effects via anti-apoptotic pathways. A clear primary receptor is not established.
Evidence base
Highest evidence
Animal model
Human trial
Studies
4
4
of which in humans
0
2
Effects recorded
4
3
Open conflicts
2
0
Documented adverse events
2
1