Comparison
CJC-1295 vs. GHK-Cu
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Growth
Cosmetic
CAS no.
no data
49557-75-7
Molecular weight
3647.3 g/mol
340.4 g/mol
Half-life
144 h
no data
Sequence
YADAIFTNSYRKVLGQLSARKLLQDIMSR-DACGHKMechanism of action
CJC-1295
Synthetic analogue of growth-hormone-releasing hormone (GHRH), modified for extended half-life via a Drug Affinity Complex (DAC) binding to albumin. Acts on the pituitary GHRH receptor and stimulates endogenous growth-hormone release.
GHK-Cu
Endogenous tripeptide (glycyl-L-histidyl-L-lysine) that chelates copper(II) ions. In skin-cell models and skin biopsies an influence on collagen synthesis, antioxidant markers, gene-expression profiles and wound-healing processes has been described. In topical use in cosmetic studies, changes in various skin parameters have been reported.
Evidence base
Highest evidence
Human trial
Human trial
Studies
3
3
of which in humans
2
1
Effects recorded
3
4
Open conflicts
1
1
Documented adverse events
3
2