Comparison
Epitalon vs. GHK-Cu
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Research other
Cosmetic
CAS no.
307297-39-8
49557-75-7
Molecular weight
390.35 g/mol
340.4 g/mol
Half-life
0.3 h
no data
Sequence
Ala-Glu-Asp-GlyGHKMechanism of action
Epitalon
Postulated mechanisms include modulation of gene expression in pinealocytes, telomerase activation (observed in cell culture studies) and influence on melatonin synthesis. A defined primary receptor is not established; the mechanistic basis rests on in-vitro and animal data from the Khavinson group.
GHK-Cu
Endogenous tripeptide (glycyl-L-histidyl-L-lysine) that chelates copper(II) ions. In skin-cell models and skin biopsies an influence on collagen synthesis, antioxidant markers, gene-expression profiles and wound-healing processes has been described. In topical use in cosmetic studies, changes in various skin parameters have been reported.
Evidence base
Highest evidence
Human trial
Human trial
Studies
4
3
of which in humans
1
1
Effects recorded
4
4
Open conflicts
1
1
Documented adverse events
1
2