Comparison
Epitalon vs. Hexarelin
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Research other
Growth
CAS no.
307297-39-8
140703-51-1
Molecular weight
390.35 g/mol
887.05 g/mol
Half-life
0.3 h
0.9 h
Sequence
Ala-Glu-Asp-GlyHis-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2Mechanism of action
Epitalon
Postulated mechanisms include modulation of gene expression in pinealocytes, telomerase activation (observed in cell culture studies) and influence on melatonin synthesis. A defined primary receptor is not established; the mechanistic basis rests on in-vitro and animal data from the Khavinson group.
Hexarelin
Hexarelin is a synthetic analog of the GHRP-6 family binding both the GH secretagogue receptor (GHSR-1a) and CD36. GHSR activation in the pituitary releases pulsatile growth hormone. Via CD36 in endothelium and myocardium, cardioprotective effects have been described in animal studies.
Evidence base
Highest evidence
Human trial
Human trial
Studies
4
4
of which in humans
1
3
Effects recorded
4
3
Open conflicts
1
0
Documented adverse events
1
1