Comparison
Epitalon vs. Bremelanotide
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Research other
Research other
CAS no.
307297-39-8
189691-06-3
Molecular weight
390.35 g/mol
1025.18 g/mol
Half-life
0.3 h
2.7 h
Sequence
Ala-Glu-Asp-GlyAc-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-OHMechanism of action
Epitalon
Postulated mechanisms include modulation of gene expression in pinealocytes, telomerase activation (observed in cell culture studies) and influence on melatonin synthesis. A defined primary receptor is not established; the mechanistic basis rests on in-vitro and animal data from the Khavinson group.
Bremelanotide
Bremelanotide is a cyclic peptide that binds non-selectively to melanocortin receptors (MC1R through MC5R) — with highest affinity at MC4R in the central nervous system. The precise role of MC4R activation in sexual behaviour is not fully understood; animal data show effects on hypothalamic circuits. Peripheral effects (blood pressure, hyperpigmentation) are attributed to MC1R/MC2R.
Evidence base
Highest evidence
Human trial
Human RCT
Studies
4
5
of which in humans
1
5
Effects recorded
4
3
Open conflicts
1
0
Documented adverse events
1
2