Comparison
GHK-Cu vs. Selank
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Cosmetic
Research other
CAS no.
49557-75-7
129954-34-3
Molecular weight
340.4 g/mol
751.85 g/mol
Half-life
no data
0.3 h
Sequence
GHKThr-Lys-Pro-Arg-Pro-Gly-ProMechanism of action
GHK-Cu
Endogenous tripeptide (glycyl-L-histidyl-L-lysine) that chelates copper(II) ions. In skin-cell models and skin biopsies an influence on collagen synthesis, antioxidant markers, gene-expression profiles and wound-healing processes has been described. In topical use in cosmetic studies, changes in various skin parameters have been reported.
Selank
Selank is a glyproline-tuftsin analog. Proposed mechanisms include modulation of the GABAergic system, effects on serotonin bioavailability, and influence on enkephalinases. Animal studies show anxiolytic and neuroprotective markers; a clear receptor target is not established.
Evidence base
Highest evidence
Human trial
Human trial
Studies
3
4
of which in humans
1
2
Effects recorded
4
3
Open conflicts
1
0
Documented adverse events
2
1