Comparison
GHK-Cu vs. Thymalin
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Cosmetic
Healing
CAS no.
49557-75-7
63958-90-7
Molecular weight
340.4 g/mol
1000 g/mol
Half-life
no data
0.5 h
Sequence
GHKno data
Mechanism of action
GHK-Cu
Endogenous tripeptide (glycyl-L-histidyl-L-lysine) that chelates copper(II) ions. In skin-cell models and skin biopsies an influence on collagen synthesis, antioxidant markers, gene-expression profiles and wound-healing processes has been described. In topical use in cosmetic studies, changes in various skin parameters have been reported.
Thymalin
Thymalin is a complex of multiple polypeptides extracted from bovine or calf thymus. Postulated mechanisms include modulation of T-lymphocyte maturation, influence on interleukin profiles and stimulation of cellular immune response. Being a multi-component preparation, individual mechanisms are difficult to disentangle. Khavinson and colleagues from St Petersburg have described the mechanism over decades in Russian publications.
Evidence base
Highest evidence
Human trial
Human trial
Studies
3
4
of which in humans
1
2
Effects recorded
4
3
Open conflicts
1
1
Documented adverse events
2
1