Comparison
Hexarelin vs. Matrixyl
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Growth
Cosmetic
CAS no.
140703-51-1
214047-00-4
Molecular weight
887.05 g/mol
802.06 g/mol
Half-life
0.9 h
no data
Sequence
His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2Palmitoyl-Lys-Thr-Thr-Lys-SerMechanism of action
Hexarelin
Hexarelin is a synthetic analog of the GHRP-6 family binding both the GH secretagogue receptor (GHSR-1a) and CD36. GHSR activation in the pituitary releases pulsatile growth hormone. Via CD36 in endothelium and myocardium, cardioprotective effects have been described in animal studies.
Matrixyl
KTTKS is a fragment of the procollagen I sequence and appears to be part of a feedback mechanism in fibroblasts: elevated concentrations signal intact collagen synthesis and downregulate new synthesis, while low concentrations stimulate it. In cell-culture studies, stimulation of collagen types I/III, elastin, fibronectin and glycosaminoglycans has been documented. The palmitoyl modification is intended to improve skin penetration; effect at the site of action (dermal fibroblasts) depends on permeation.
Evidence base
Highest evidence
Human trial
Human RCT
Studies
4
5
of which in humans
3
2
Effects recorded
3
3
Open conflicts
0
0
Documented adverse events
1
1