Comparison
Hexarelin vs. TB-500
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Growth
Healing
CAS no.
140703-51-1
no data
Molecular weight
887.05 g/mol
888 g/mol
Half-life
0.9 h
no data
Sequence
His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2Ac-LKKTETQMechanism of action
Hexarelin
Hexarelin is a synthetic analog of the GHRP-6 family binding both the GH secretagogue receptor (GHSR-1a) and CD36. GHSR activation in the pituitary releases pulsatile growth hormone. Via CD36 in endothelium and myocardium, cardioprotective effects have been described in animal studies.
TB-500
Synthetic fragment of the endogenous protein Thymosin Beta-4. In preclinical models, an influence on cell migration, actin sequestration and neovascularisation has been described. Robust human pharmacokinetic data are not publicly available.
Evidence base
Highest evidence
Human trial
Animal model
Studies
4
3
of which in humans
3
0
Effects recorded
3
4
Open conflicts
0
1
Documented adverse events
1
2