Comparison
Hexarelin vs. Thymalin
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Growth
Healing
CAS no.
140703-51-1
63958-90-7
Molecular weight
887.05 g/mol
1000 g/mol
Half-life
0.9 h
0.5 h
Sequence
His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2no data
Mechanism of action
Hexarelin
Hexarelin is a synthetic analog of the GHRP-6 family binding both the GH secretagogue receptor (GHSR-1a) and CD36. GHSR activation in the pituitary releases pulsatile growth hormone. Via CD36 in endothelium and myocardium, cardioprotective effects have been described in animal studies.
Thymalin
Thymalin is a complex of multiple polypeptides extracted from bovine or calf thymus. Postulated mechanisms include modulation of T-lymphocyte maturation, influence on interleukin profiles and stimulation of cellular immune response. Being a multi-component preparation, individual mechanisms are difficult to disentangle. Khavinson and colleagues from St Petersburg have described the mechanism over decades in Russian publications.
Evidence base
Highest evidence
Human trial
Human trial
Studies
4
4
of which in humans
3
2
Effects recorded
3
3
Open conflicts
0
1
Documented adverse events
1
1