Comparison
Hexarelin vs. Thymosin Alpha-1
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Growth
Healing
CAS no.
140703-51-1
62304-98-7
Molecular weight
887.05 g/mol
3108.32 g/mol
Half-life
0.9 h
2 h
Sequence
His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2Ac-SDAAVDTSSEITTKDLKEKKEVVEEAENMechanism of action
Hexarelin
Hexarelin is a synthetic analog of the GHRP-6 family binding both the GH secretagogue receptor (GHSR-1a) and CD36. GHSR activation in the pituitary releases pulsatile growth hormone. Via CD36 in endothelium and myocardium, cardioprotective effects have been described in animal studies.
Thymosin Alpha-1
Thymosin Alpha-1 is an N-terminally acetylated peptide originally isolated from the thymus. It modulates T-lymphocyte maturation and function and acts on dendritic cells via Toll-like receptors (TLR9 / TLR2). In preclinical and some clinical studies, increased interferon-gamma responses and altered T-cell subpopulations have been reported.
Evidence base
Highest evidence
Human trial
Human RCT
Studies
4
2
of which in humans
3
2
Effects recorded
3
3
Open conflicts
0
1
Documented adverse events
1
1