Comparison
Histrelin vs. Nafarelin
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Research other
Research other
CAS no.
220810-26-4
no data
Molecular weight
1323.52 g/mol
no data
Half-life
no data
no data
Sequence
no data
no data
Mechanism of action
Histrelin
Continuous GnRH-agonist stimulation downregulates and desensitises the pituitary GnRH receptors — after the initial rise, LH, FSH and the sex hormones fall persistently.
Nafarelin
Nafarelin is a potent GnRH agonist: after an initial stimulation ('flare'), continuous receptor occupancy leads to downregulation and thereby suppression of LH, FSH and the downstream sex hormones.
Evidence base
Highest evidence
Human RCT
Human RCT
Studies
0
0
of which in humans
0
0
Effects recorded
2
2
Open conflicts
0
0
Documented adverse events
1
1
Legal status
Full entries
Frequently asked questions
- What is the difference between Histrelin and Nafarelin?
- Histrelin is classified as "Research other", while Nafarelin is classified as "Research other". Histrelin: Histrelin is a nonapeptide GnRH agonist delivered as a once-yearly implant. Approved for central precocious puberty in children (Supprelin LA) and advanced prostate cancer (Vantas). Nafarelin: Nafarelin is a GnRH agonist and the only member of this class delivered as a nasal spray. It is approved for treating endometriosis and central precocious puberty. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Histrelin or Nafarelin?
- The highest available evidence level is "Human RCT" for Histrelin and "Human RCT" for Nafarelin. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Histrelin and Nafarelin in Germany and the United States?
- Germany: Histrelin — Prescription, Nafarelin — Prescription. United States: Histrelin — Prescription, Nafarelin — Prescription. These are factual summaries with source and review date on the individual pages.