Comparison
Icatibant vs. Nafarelin
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Research other
Research other
CAS no.
138614-30-9
no data
Molecular weight
1304.52 g/mol
no data
Half-life
no data
no data
Sequence
no data
no data
Mechanism of action
Icatibant
Icatibant competitively blocks the bradykinin B2 receptor. Because bradykinin mediates the vascular permeability, swelling and pain typical of hereditary angioedema, the blockade interrupts the acute attack.
Nafarelin
Nafarelin is a potent GnRH agonist: after an initial stimulation ('flare'), continuous receptor occupancy leads to downregulation and thereby suppression of LH, FSH and the downstream sex hormones.
Evidence base
Highest evidence
Human RCT
Human RCT
Studies
1
0
of which in humans
1
0
Effects recorded
1
2
Open conflicts
0
0
Documented adverse events
1
1
Legal status
Full entries
Frequently asked questions
- What is the difference between Icatibant and Nafarelin?
- Icatibant is classified as "Research other", while Nafarelin is classified as "Research other". Icatibant: Icatibant is a synthetic decapeptide and selective antagonist of the bradykinin B2 receptor. It is approved to treat acute attacks of hereditary angioedema (HAE). Nafarelin: Nafarelin is a GnRH agonist and the only member of this class delivered as a nasal spray. It is approved for treating endometriosis and central precocious puberty. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Icatibant or Nafarelin?
- The highest available evidence level is "Human RCT" for Icatibant and "Human RCT" for Nafarelin. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Icatibant and Nafarelin in Germany and the United States?
- Germany: Icatibant — Prescription, Nafarelin — Prescription. United States: Icatibant — Prescription, Nafarelin — Prescription. These are factual summaries with source and review date on the individual pages.