Comparison
Icatibant vs. Sekretin
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Research other
Research other
CAS no.
138614-30-9
no data
Molecular weight
1304.52 g/mol
3055.5 g/mol
Half-life
no data
no data
Sequence
no data
no data
Mechanism of action
Icatibant
Icatibant competitively blocks the bradykinin B2 receptor. Because bradykinin mediates the vascular permeability, swelling and pain typical of hereditary angioedema, the blockade interrupts the acute attack.
Sekretin
Secretin binds the Gs-coupled secretin receptor (SCTR) on pancreatic duct cells, opens CFTR chloride channels and triggers secretion of bicarbonate-rich pancreatic fluid and bile flow.
Evidence base
Highest evidence
Human RCT
Human trial
Studies
1
0
of which in humans
1
0
Effects recorded
1
2
Open conflicts
0
0
Documented adverse events
1
1
Legal status
Full entries
Frequently asked questions
- What is the difference between Icatibant and Sekretin?
- Icatibant is classified as "Research other", while Sekretin is classified as "Research other". Icatibant: Icatibant is a synthetic decapeptide and selective antagonist of the bradykinin B2 receptor. It is approved to treat acute attacks of hereditary angioedema (HAE). Sekretin: Secretin is a 27-amino-acid hormone that regulates pancreatic bicarbonate secretion. As ChiRhoStim it is FDA-approved as a diagnostic agent (pancreatic function test, gastrinoma test, secretin-enhanced MRCP). This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Icatibant or Sekretin?
- The highest available evidence level is "Human RCT" for Icatibant and "Human trial" for Sekretin. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Icatibant and Sekretin in Germany and the United States?
- Germany: Icatibant — Prescription, Sekretin — Prescription. United States: Icatibant — Prescription, Sekretin — Prescription. These are factual summaries with source and review date on the individual pages.