Comparison
Ipamorelin vs. Selank
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Growth
Research other
CAS no.
170851-70-4
129954-34-3
Molecular weight
711.86 g/mol
751.85 g/mol
Half-life
2 h
0.3 h
Sequence
Aib-His-D-2-Nal-D-Phe-Lys-NH2Thr-Lys-Pro-Arg-Pro-Gly-ProMechanism of action
Ipamorelin
Ipamorelin is a selective agonist at the GH secretagogue receptor (GHSR-1a). Compared to GHRP-2 and GHRP-6 its selectivity for the growth-hormone axis is higher; ACTH, cortisol and prolactin are not significantly stimulated in clinical studies. This selectivity was the main reason for its development over older GHRPs.
Selank
Selank is a glyproline-tuftsin analog. Proposed mechanisms include modulation of the GABAergic system, effects on serotonin bioavailability, and influence on enkephalinases. Animal studies show anxiolytic and neuroprotective markers; a clear receptor target is not established.
Evidence base
Highest evidence
Human RCT
Human trial
Studies
4
4
of which in humans
3
2
Effects recorded
3
3
Open conflicts
1
0
Documented adverse events
1
1