Comparison
Leuprorelin vs. Sekretin
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Research other
Research other
CAS no.
53714-56-0
no data
Molecular weight
1209.4 g/mol
3055.5 g/mol
Half-life
3 h
no data
Sequence
Pyr-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEtno data
Mechanism of action
Leuprorelin
Leuprorelin is a GnRH-receptor agonist. After binding to pituitary GnRH receptors, it first causes a transient surge in luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release — the so-called flare. With continuous, non-pulsatile exposure the receptors are downregulated and desensitized, suppressing gonadotropin secretion and consequently lowering sex steroids (testosterone or estradiol) to low levels. This mechanism underlies the literature-described use in hormone-dependent conditions.
Sekretin
Secretin binds the Gs-coupled secretin receptor (SCTR) on pancreatic duct cells, opens CFTR chloride channels and triggers secretion of bicarbonate-rich pancreatic fluid and bile flow.
Evidence base
Highest evidence
Human RCT
Human trial
Studies
4
0
of which in humans
4
0
Effects recorded
4
2
Open conflicts
1
0
Documented adverse events
3
1
Legal status
Full entries
Frequently asked questions
- What is the difference between Leuprorelin and Sekretin?
- Leuprorelin is classified as "Research other", while Sekretin is classified as "Research other". Leuprorelin: Leuprorelin (also leuprolide) is a synthetic nonapeptide analogue of gonadotropin-releasing hormone (GnRH/LHRH). It is an approved prescription medicine in several jurisdictions, including for advanced prostate cancer, endometriosis, uterine fibroids and central precocious puberty. This page neutrally summarizes the evidence base and legal status and is not a usage or dosing recommendation. Sekretin: Secretin is a 27-amino-acid hormone that regulates pancreatic bicarbonate secretion. As ChiRhoStim it is FDA-approved as a diagnostic agent (pancreatic function test, gastrinoma test, secretin-enhanced MRCP). This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Leuprorelin or Sekretin?
- The highest available evidence level is "Human RCT" for Leuprorelin and "Human trial" for Sekretin. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Leuprorelin and Sekretin in Germany and the United States?
- Germany: Leuprorelin — Prescription, Sekretin — Prescription. United States: Leuprorelin — Prescription, Sekretin — Prescription. These are factual summaries with source and review date on the individual pages.